RRC ID 65417
Author Shimura K, Mabuchi S, Komura N, Yokoi E, Kozasa K, Sasano T, Kawano M, Matsumoto Y, Watabe T, Kodama M, Hashimoto K, Sawada K, Hatazawa J, Kimura T.
Title Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer.
Journal Sci Rep
Abstract We investigated the prognostic significance and the underlying mechanism of increased bone marrow (BM) 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer. A list of patients diagnosed with cervical, endometrial, and ovarian cancer from January 2008 to December 2014 were identified. Then, through chart reviews, 559 patients who underwent staging by FDG-positron emission tomography (PET)/computed tomography (CT) and subsequent surgical resection were identified, and their clinical data were reviewed retrospectively. BM FDG-uptake was evaluated using maximum standardized uptake value (SUVmax) and BM-to-aorta uptake ratio (BAR). As a result, we have found that increased BAR was observed in 20 (8.7%), 21 (13.0%), 21 (12.6%) of cervical, endometrial, and ovarian cancer, respectively, and was associated with significantly shorter survival. Increased BAR was also closely associated with increased granulopoiesis. In vitro and in vivo experiments revealed that tumor-derived granulocyte colony-stimulating factor (G-CSF) was involved in the underlying causative mechanism of increased BM FDG-uptake, and that immune suppression mediated by G-CSF-induced myeloid-derived suppressor cells (MDSCs) is responsible for the poor prognosis of this type of cancer. In conclusion, increased BM FDG-uptake, as represented by increased BAR, is an indicator of poor prognosis in patients with gynecological cancer.
Volume 11(1)
Pages 2257
Published 2021-1-26
DOI 10.1038/s41598-021-81298-1
PII 10.1038/s41598-021-81298-1
PMID 33500424
PMC PMC7838412
MeSH Adult Aged Aged, 80 and over Animals Aorta / metabolism Bone Marrow / metabolism* Cell Line, Tumor Female Fluorodeoxyglucose F18 / pharmacokinetics* Genital Neoplasms, Female / diagnostic imaging Genital Neoplasms, Female / metabolism* Granulocyte Colony-Stimulating Factor / metabolism Humans Mice, Inbred C57BL Middle Aged Multivariate Analysis Myeloid-Derived Suppressor Cells / metabolism Positron Emission Tomography Computed Tomography Prognosis Progression-Free Survival Rats
IF 3.998
DNA material pCAmGCSF (RDB04277) pCAZ 2 (RDB01870)