RRC ID 6557
Author Kaneda M, Zhang D, Bhattacharjee R, Nakahama K, Arii S, Morita I.
Title Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43.
Journal Cancer Lett.
Abstract The anti-cancer potential of vitamin K(2) (VK(2)) in hepatoma has gained considerable attention but the underlying mechanisms are unclear. Treatment of HuH7 hepatoma cells with VK(2) produced a normal liver phenotype. Following treatment of cells with VK(2), there was an increase in gap junctional intercellular communication activity, accompanied by up-regulation of connexin 32 (Cx32), dominantly expressed in normal hepatocyte. In contrast, Cx43 expression was inhibited. Moreover, the effect of VK(2) on Cx32 was abolished by over-expression of Cx43. Taken together, we propose that the anti-tumor effect of VK(2) is at least partly due to a decrease in Cx43 promoter activity.
Volume 263(1)
Pages 53-60
Published 2008-5-8
DOI 10.1016/j.canlet.2007.12.019
PII S0304-3835(07)00628-3
PMID 18249064
MeSH Base Sequence Carcinoma, Hepatocellular / genetics Carcinoma, Hepatocellular / pathology* Cell Line, Tumor Connexins / antagonists & inhibitors* Connexins / genetics DNA Primers Humans Immunohistochemistry Liver Neoplasms / genetics Liver Neoplasms / pathology* Promoter Regions, Genetic Vitamin K 2 / pharmacology*
IF 6.491
Times Cited 9
Human and Animal Cells