| RRC ID |
65593
|
| Author |
Kuroda T, Mizutani Y, Cançado CRX, Podlesnik CA.
|
| Title |
Reversal learning and resurgence of operant behavior in zebrafish (Danio rerio).
|
| Journal |
Behav Processes
|
| Abstract |
Zebrafish are used extensively as vertebrate animal models in biomedical research for having such features as a fully sequenced genome and transparent embryo. Yet, operant-conditioning studies with this species are scarce. The present study investigated reversal learning and resurgence of operant behavior in zebrafish. A target response (approaching a sensor) was reinforced in Phase 1. In Phase 2, the target response was extinguished while reinforcing an alternative response (approaching a different sensor). In Phase 3, extinction was in effect for the target and alternative responses. Reversal learning was demonstrated when responding tracked contingency changes between Phases 1 and 2. Moreover, resurgence occurred in 10 of 13 fish in Phase 3: Target response rates increased transiently and exceeded rates of an unreinforced control response. The present study provides the first evidence with zebrafish supporting reversal learning between discrete operant responses and a laboratory model of relapse. These findings open the possibility to assessing genetic influences of operant behavior generally and in models of relapse (e.g., resurgence, renewal, reinstatement).
|
| Volume |
142
|
| Pages |
79-83
|
| Published |
2017-9-1
|
| DOI |
10.1016/j.beproc.2017.06.004
|
| PII |
S0376-6357(17)30186-9
|
| PMID |
28633953
|
| MeSH |
Animals
Conditioning, Operant*
Extinction, Psychological
Models, Animal
Reinforcement, Psychology
Reversal Learning*
Zebrafish*
|
| IF |
1.846
|
| Resource |
| Zebrafish |
RIKEN WT |
