RRC ID 65594
Author Kuroda T, Mizutani Y, Cançado CRX, Podlesnik CA.
Title Operant models of relapse in zebrafish (Danio rerio): Resurgence, renewal, and reinstatement.
Journal Behav Brain Res
Abstract Zebrafish are a widely used animal model in biomedical research, as an alternative to mammals, for having features such as a fully sequenced genome, high fecundity, and low-cost maintenance, but behavioral research with these fish remains scarce. The present study investigated whether zebrafish could be a new animal model for studies on the relapse of behavior (e.g., addiction and overeating) after the behavior has been extinguished. Specifically, we examined whether zebrafish would show three different types of relapse commonly studied with other species: resurgence, renewal, and reinstatement. For resurgence, a target response (i.e., approaching a sensor) was established by presenting a reinforcer (i.e., shrimp eggs) contingent upon the response in Phase 1; the target response was extinguished while introducing reinforcement for an alternative response in Phase 2; neither response produced the reinforcer in Phase 3. For renewal, a target response was established under Context A in Phase 1 and was extinguished under Context B in Phase 2; the fish were placed back in Context A in Phase 3, where extinction remained in effect. For reinstatement, a target response was established in Phase 1 and was extinguished in Phase 2; the reinforcer was presented independently of responding in Phase 3. Each type of relapse occurred in Phase 3. These results replicate and extend previous findings on relapse to a new species and suggest that zebrafish can be a useful animal model for studying the interactions of biological and environmental factors that lead to relapse.
Volume 335
Pages 215-222
Published 2017-9-29
DOI 10.1016/j.bbr.2017.08.023
PII S0166-4328(17)31214-7
PMID 28830819
MeSH Animals Behavior, Animal / physiology* Conditioning, Operant / physiology* Extinction, Psychological / physiology* Female Male Models, Animal Recurrence Reinforcement Schedule Reinforcement, Psychology Reward Zebrafish / physiology
IF 2.977
Zebrafish RIKEN WT