| RRC ID |
65619
|
| Author |
Abley K, Formosa-Jordan P, Tavares H, Chan EY, Afsharinafar M, Leyser O, Locke JC.
|
| Title |
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
|
| Journal |
Elife
|
| Abstract |
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms. We show extensive variation in seed germination time variability between Arabidopsis accessions and use a multiparent recombinant inbred population to identify two genetic loci involved in this trait. Both loci include genes implicated in modulating abscisic acid (ABA) sensitivity. Mutually antagonistic regulation between ABA, which represses germination, and gibberellic acid (GA), which promotes germination, underlies the decision to germinate and can act as a bistable switch. A simple stochastic model of the ABA-GA network shows that modulating ABA sensitivity can generate the range of germination time distributions we observe experimentally. We validate the model by testing its predictions on the effects of exogenous hormone addition. Our work provides a foundation for understanding the mechanism and functional role of phenotypic variability in germination time.
|
| Volume |
10
|
| Published |
2021-6-1
|
| DOI |
10.7554/eLife.59485
|
| PII |
59485
|
| PMID |
34059197
|
| PMC |
PMC8169117
|
| MeSH |
Abscisic Acid / pharmacology*
Arabidopsis / drug effects*
Arabidopsis / genetics
Arabidopsis / growth & development
Gene Expression Regulation, Plant
Genetic Loci
Germination / drug effects*
Gibberellins / pharmacology*
Models, Biological
Phenotype
Plants, Genetically Modified / drug effects
Plants, Genetically Modified / genetics
Plants, Genetically Modified / growth & development
Seeds / drug effects*
Seeds / genetics
Seeds / growth & development
Signal Transduction
Stochastic Processes
Time Factors
|
| IF |
7.08
|
| Resource |
| Arabidopsis / Cultured plant cells, genes |
pst21966 |
