Reference - Detail
| RRC ID | 65635 |
|---|---|
| Author | Mawas AS, Amatya VJ, Suzuki R, Kushitani K, Mohi El-Din MM, Takeshima Y. |
| Title | PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells. |
| Journal | Int J Oncol |
| Abstract |
Malignant mesothelioma is a major asbestos-related cancer with prolonged time lapse from the first exposure of asbestos to the development of mesothelioma. Most of mesothelioma patients show very poor prognosis, thus, an urgent improvement of its treatment is required by development of novel therapeutic strategies. RNA interference (RNAi) is a powerful tool in post-genomic research and cancer therapy through inhibition of gene expression. In the present study, we analyzed the function of PIM1 on mesothelioma cell lines with its knockdown by siRNA transfection. Here, we report that the downregulation of PIM1 led to suppression of cell proliferation by cell cycle arrest at G1 phase and suppression of cell invasion and migration. Considering the mesothelioma as rapidly growing invasive cancer, downregulation of PIM1 may have a potential role for therapeutic management of malignant mesothelioma. |
| Volume | 50(3) |
| Pages | 1029-1034 |
| Published | 2017-3-1 |
| DOI | 10.3892/ijo.2017.3863 |
| PMID | 28197633 |
| MeSH | Apoptosis / genetics Cell Line, Tumor Cell Movement / genetics* Cell Proliferation / genetics* Cell Survival / genetics G1 Phase Cell Cycle Checkpoints / genetics* Humans Lung Neoplasms / genetics* Lung Neoplasms / pathology* Mesothelioma / genetics* Mesothelioma / pathology* Mesothelioma, Malignant Neoplasm Invasiveness / genetics Proto-Oncogene Proteins c-pim-1 / genetics* RNA Interference RNA, Small Interfering / genetics |
| IF | 3.899 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ACC-MESO-1(RCB2292) |