論文 - 詳細
| RRC ID | 65662 |
|---|---|
| 著者 | Ando H, Eshima K, Ishida T. |
| タイトル | Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Extracellular pH (pHe) of tumor cells is characteristic of tumor microenvironment (TME). Acidic TME impairs the responses of tumors to some anti-cancer chemotherapies. In this study, we showed that daily oral dosing of sodium potassium citrate (K/Na citrate) increased blood HCO3- concentrations, corresponding to increase of HCO3- concentrations and pHs in urine, and neutralized the tumor pHe. Neutralization of acidic TME by alkaline substance like HCO3-, an active metabolite of K/Na citrate, well potentiated the therapeutic effect of anticancer agent TS-1®, an orally active 5-fuluoro-uracil derivative, in Panc-1 pancreatic cancer-xenograft murine model. Neutralization of acidic TME by using an alkaline K/Na citrate is a smart approach for enhancement of the therapeutic effects of anticancer agents for pancreatic cancer in the end stage. |
| 巻・号 | 44(2) |
| ページ | 266-270 |
| 公開日 | 2021-1-1 |
| DOI | 10.1248/bpb.b20-00825 |
| PMID | 33518679 |
| MeSH | Administration, Oral Animals Antacids / administration & dosage* Antacids / pharmacokinetics Cell Line, Tumor Drug Combinations Drug Synergism Extracellular Space / chemistry Extracellular Space / drug effects Female Humans Hydrogen-Ion Concentration / drug effects* Mice Oxonic Acid / administration & dosage* Oxonic Acid / pharmacokinetics Oxonic Acid / therapeutic use Pancreatic Neoplasms / drug therapy* Pancreatic Neoplasms / pathology Potassium Citrate / administration & dosage Potassium Citrate / pharmacokinetics Sodium Citrate / administration & dosage Sodium Citrate / pharmacokinetics Tegafur / administration & dosage* Tegafur / pharmacokinetics Tegafur / therapeutic use Tumor Microenvironment / drug effects* Xenograft Model Antitumor Assays |
| IF | 1.863 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |