Reference - Detail
| RRC ID | 65888 |
|---|---|
| Author | Lin Q, Manley J, Helmreich M, Schlumm F, Li JM, Robson DN, Engert F, Schier A, Nöbauer T, Vaziri A. |
| Title | Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level. |
| Journal | Cell |
| Abstract |
Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning. |
| Volume | 180(3) |
| Pages | 536-551.e17 |
| Published | 2020-2-6 |
| DOI | 10.1016/j.cell.2019.12.018 |
| PII | S0092-8674(19)31380-7 |
| PMID | 31955849 |
| PMC | PMC7299501 |
| MeSH | Animals Behavior, Animal / physiology Brain Mapping / methods Cerebellum / physiology* Cerebrum / physiology Cognition / physiology Conditioning, Operant / physiology Decision Making / physiology* Goals Habenula / physiology Hot Temperature Larva / physiology Motor Activity / physiology Movement Neurons / physiology Psychomotor Performance / physiology Reaction Time / physiology* Rhombencephalon / physiology Zebrafish / physiology* |
| IF | 38.637 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 129 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(gad1b:|R|-GFP), gSA2AzGFF152B |