| RRC ID |
65889
|
| 著者 |
Mateus R, Holtzer L, Seum C, Hadjivasiliou Z, Dubois M, Jülicher F, Gonzalez-Gaitan M.
|
| タイトル |
BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signaling forms a two-dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-law. Gradient scaling and amplitude power-laws are signatures of growth control by time derivatives of morphogenetic signaling: cell division correlates with the fold change over time of the cellular signaling levels. We show that Smoc1 regulates BMP gradient scaling and growth in the fin. Smoc1 scales the gradient by means of a feedback loop: Smoc1 is a BMP agonist and BMP signaling represses Smoc1 expression. Our work uncovers a layer of morphogen regulation during vertebrate appendage development.
|
| 巻・号 |
30(12)
|
| ページ |
4292-4302.e7
|
| 公開日 |
2020-3-24
|
| DOI |
10.1016/j.celrep.2020.03.024
|
| PII |
S2211-1247(20)30338-7
|
| PMID |
32209485
|
| PMC |
PMC7109522
|
| MeSH |
Animal Fins / anatomy & histology
Animal Fins / growth & development
Animal Fins / metabolism*
Animal Fins / ultrastructure
Animals
Animals, Genetically Modified
Anisotropy
Bone Morphogenetic Proteins / metabolism*
Larva / ultrastructure
Organ Size
Phenotype
Signal Transduction*
Zebrafish / metabolism*
Zebrafish Proteins / metabolism
|
| IF |
8.109
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(EF1α:mAG-zGem(1/100)) rw0410h |
