論文 - 詳細
| RRC ID | 65908 |
|---|---|
| 著者 | Fotso GW, Kamga J, Ngameni B, Uesugi S, Ohno M, Kimura KI, Momma H, Kwon E, Furuno H, Shiono Y, Ingrid SK, Yeboah SO, Ngadjui BT. |
| タイトル | Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). |
| ジャーナル | Nat Prod Res |
| Abstract |
A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1-6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa. |
| 巻・号 | 31(17) |
| ページ | 1981-1987 |
| 公開日 | 2017-9-1 |
| DOI | 10.1080/14786419.2016.1269097 |
| PMID | 28103742 |
| MeSH | Albizzia / chemistry Albizzia / metabolism* Antineoplastic Agents, Phytogenic / chemistry* Antineoplastic Agents, Phytogenic / pharmacology* Benzopyrans / chemistry Benzopyrans / isolation & purification Benzopyrans / pharmacology Cell Proliferation / drug effects Drug Screening Assays, Antitumor / methods Flavonoids / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* HL-60 Cells HeLa Cells Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Molecular Structure Secondary Metabolism Steroids / chemistry* Steroids / pharmacology* |
| IF | 2.158 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |