論文 - 詳細
| RRC ID | 65915 |
|---|---|
| 著者 | Matsuda M, Sakaizumi M. |
| タイトル | Evolution of the sex-determining gene in the teleostean genus Oryzias. |
| ジャーナル | Gen Comp Endocrinol |
| Abstract |
In the genetic sex determination of vertebrates, the gonadal sex depends on the combination of sex chromosomes that a zygote possesses. Despite the discovery of the sex-determining gene (SRY/Sry) in mammals in 1990s, the sex-determining gene in non-mammalian vertebrates remained an enigma for over a decade. In most mammals, the male-inducing master sex-determining gene is located on the Y chromosome and is therefore absent from XX females. A second sex-determining gene, Dmy, was described in the Oryzias latipes in 2002 and has a DNA-binding motif that is different from the motif in the mammalian sex-determining gene SRY or Sry. Dmy is also located on the Y chromosome and is therefore absent in XX females. Seven other sex-determining genes, including candidate genes, are now known in birds, a frog species, and 5 fish species. These findings over the past twenty years have increased our knowledge of sex-determining genes and sex chromosomes among vertebrates. Here, we review recent advances in our understanding of sex-determining genes and genetic sex determination systems in fish, especially those of the Oryzias species, which are described in detail. The facts suggest some patterns of how new sex-determining genes emerged and evolved. We believe that these facts are common not only in Oryzias but also in other fish species. This knowledge will help to elucidate the conserved mechanisms from which various sex-determining mechanisms have evolved. |
| 巻・号 | 239 |
| ページ | 80-88 |
| 公開日 | 2016-12-1 |
| DOI | 10.1016/j.ygcen.2015.10.004 |
| PII | S0016-6480(15)30002-2 |
| PMID | 26449160 |
| MeSH | Animals Evolution, Molecular* Female Genes, sry* Male Mutation Oryzias / classification Oryzias / genetics* Sex Chromosomes Sex Determination Processes / genetics* Transcription Factors / genetics Y Chromosome |
| IF | 2.428 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
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| リソース情報 | |
| メダカ | |