論文 - 詳細
RRC ID | 65934 |
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著者 | Fujihara K, Takahashi K, Koyama K, Kinoshita K. |
タイトル | Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells. |
ジャーナル | J Nat Med |
Abstract |
Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated. |
巻・号 | 71(4) |
ページ | 606-616 |
公開日 | 2017-10-1 |
DOI | 10.1007/s11418-017-1082-9 |
PII | 10.1007/s11418-017-1082-9 |
PMID | 28497306 |
MeSH | Animals Cactaceae / chemistry* Cell Line, Tumor Glycosides / chemistry Glycosides / isolation & purification Melanins / biosynthesis* Melanoma, Experimental / metabolism* Molecular Structure Oleanolic Acid / analogs & derivatives* Oleanolic Acid / chemistry Oleanolic Acid / isolation & purification Oleanolic Acid / pharmacology Plant Extracts / chemistry Plant Extracts / pharmacology* Saponins / chemistry Saponins / isolation & purification Saponins / pharmacology* Triterpenes / chemistry Triterpenes / isolation & purification Triterpenes / pharmacology* |
IF | 2.055 |
リソース情報 | |
ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |