RRC ID |
6595
|
著者 |
Tianero MD, Hanif N, de Voogd NJ, van Soest RW, Tanaka J.
|
タイトル |
A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.
|
ジャーナル |
Chem Biodivers
|
Abstract |
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.
|
巻・号 |
6(9)
|
ページ |
1374-7
|
公開日 |
2009-9-1
|
DOI |
10.1002/cbdv.200800199
|
PMID |
19774600
|
MeSH |
Animals
Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / toxicity
Cell Line
Fatty Acids, Unsaturated / chemistry*
Fatty Acids, Unsaturated / isolation & purification
Fatty Acids, Unsaturated / toxicity
Microbial Sensitivity Tests
Porifera / chemistry*
Rats
Thiophenes / chemistry*
Thiophenes / isolation & purification
Thiophenes / toxicity
|
IF |
2.039
|
引用数 |
12
|
WOS 分野
|
CHEMISTRY, MULTIDISCIPLINARY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
|