論文 - 詳細
| RRC ID | 6595 |
|---|---|
| 著者 | Tianero MD, Hanif N, de Voogd NJ, van Soest RW, Tanaka J. |
| タイトル | A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis. |
| ジャーナル | Chem Biodivers |
| Abstract |
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively. |
| 巻・号 | 6(9) |
| ページ | 1374-7 |
| 公開日 | 2009-9-1 |
| DOI | 10.1002/cbdv.200800199 |
| PMID | 19774600 |
| MeSH | Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / toxicity Cell Line Fatty Acids, Unsaturated / chemistry* Fatty Acids, Unsaturated / isolation & purification Fatty Acids, Unsaturated / toxicity Microbial Sensitivity Tests Porifera / chemistry* Rats Thiophenes / chemistry* Thiophenes / isolation & purification Thiophenes / toxicity |
| IF | 2.039 |
| 引用数 | 12 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |