論文 - 詳細
| RRC ID | 65955 |
|---|---|
| 著者 | Hosoda K, Koyama N, Hamamoto H, Yagi A, Uchida R, Kanamoto A, Tomoda H. |
| タイトル | Evaluation of Anti-Mycobacterial Compounds in a Silkworm Infection Model with Mycobacteroides abscessus. |
| ジャーナル | Molecules |
| Abstract |
Among four mycobacteria, Mycobacterium avium, M. intracellulare, M. bovis BCG and Mycobacteroides (My.) abscessus, we established a silkworm infection assay with My. abscessus. When silkworms (fifth-instar larvae, n = 5) were infected through the hemolymph with My. abscessus (7.5 × 107 CFU/larva) and bred at 37 °C, they all died around 40 h after injection. Under the conditions, clarithromycin and amikacin, clinically used antimicrobial agents, exhibited therapeutic effects in a dose-dependent manner. Furthermore, five kinds of microbial compounds, lariatin A, nosiheptide, ohmyungsamycins A and B, quinomycin and steffimycin, screened in an in vitro assay to observe anti-My. abscessus activity from 400 microbial products were evaluated in this silkworm infection assay. Lariatin A and nosiheptide exhibited therapeutic efficacy. The silkworm infection model with My. abscessus is useful to screen for therapeutically effective anti-My. abscessus antibiotics. |
| 巻・号 | 25(21) |
| 公開日 | 2020-10-27 |
| DOI | 10.3390/molecules25214971 |
| PII | molecules25214971 |
| PMID | 33121091 |
| PMC | PMC7663337 |
| MeSH | Animals Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / pharmacology* Bombyx Disease Models, Animal Drug Evaluation, Preclinical Mycobacterium abscessus / drug effects Mycobacterium abscessus / physiology* |
| IF | 3.267 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| カイコ | |