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RRC ID 65994
Author Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada
Title Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds
Journal Journal of Medicinal Chemistry
Volume 58
Pages 9510-9521
Published 2015-12-24
DOI 10.1021/acs.jmedchem.5b00792
PMID 26613420
MeSH Adamantane / analogs & derivatives* Adamantane / chemistry* Adamantane / pharmacology Calcitriol / analogs & derivatives* Calcitriol / chemistry Calcitriol / pharmacology Cell Line, Tumor Crystallography, X-Ray Drug Partial Agonism HEK293 Cells Humans Molecular Structure Organ Specificity Receptors, Calcitriol / agonists Receptors, Calcitriol / antagonists & inhibitors Receptors, Calcitriol / metabolism Stereoisomerism Structure-Activity Relationship Transcriptional Activation
IF 6.205
Resource
Human and Animal Cells THP-1(RCB1189) U937 293(RCB1637) MG-63(RCB1890)