| RRC ID |
66005
|
| 著者 |
Cherng BW, Islam T, Torigoe M, Tsuboi T, Okamoto H.
|
| タイトル |
The Dorsal Lateral Habenula-Interpeduncular Nucleus Pathway Is Essential for Left-Right-Dependent Decision Making in Zebrafish.
|
| ジャーナル |
Cell Rep
|
| Abstract |
How animals behave using suitable information to adapt to the environment is not well known. We address this issue by devising an automated system to let zebrafish exploit either internal (choice of left or right turn) or external (choice of cue color) navigation information to achieve operant behavior by reward reinforcement learning. The results of behavioral task with repeated rule shift indicate that zebrafish can learn operant behavior using both internal-directional and external-cued information. The learning time is reduced as rule shifts are repeated, revealing the capacity of zebrafish to adaptively retrieve the suitable rule memory after training. Zebrafish with an impairment in the neural pathway from the lateral subregion of the dorsal habenula to the interpeduncular nucleus, known to be potentiated in the winners of social conflicts, show specific defects in the application of the internal-directional rule, suggesting the dual roles of this pathway.
|
| 巻・号 |
32(11)
|
| ページ |
108143
|
| 公開日 |
2020-9-15
|
| DOI |
10.1016/j.celrep.2020.108143
|
| PII |
S2211-1247(20)31132-3
|
| PMID |
32937118
|
| MeSH |
Animals
Animals, Genetically Modified
Brain / physiology
Conditioning, Operant / physiology
Decision Making / physiology
Feeding Behavior / physiology*
Functional Laterality / physiology*
Habenula / metabolism
Habenula / physiology*
Interpeduncular Nucleus / physiology
Neural Pathways / physiology
Zebrafish
|
| IF |
8.109
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(narp:GAL4VP16)rw0143a
Tg(UAS:nfsB-mCherry)rw0144
Tg(UAS:TeTxLC)
RIKEN WT |
