| RRC ID |
66015
|
| 著者 |
Palumbo F, Serneels B, Pelgrims R, Yaksi E.
|
| タイトル |
The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a changing environment. We show that juvenile zebrafish can perform conditioned place avoidance learning, with improving performance across development. Ablation of the dorsolateral habenula (dlHb), a brain region involved in associative learning and prediction of outcomes, leads to an unexpected improvement in performance and delayed memory extinction. Interestingly, the control animals exhibit rapid adaptation to a changing learning rule, whereas dlHb-ablated animals fail to adapt. Altogether, our results show that the dlHb plays a central role in switching animals' strategies while integrating new evidence with prior experience.
|
| 巻・号 |
32(8)
|
| ページ |
108054
|
| 公開日 |
2020-8-25
|
| DOI |
10.1016/j.celrep.2020.108054
|
| PII |
S2211-1247(20)31039-1
|
| PMID |
32846116
|
| PMC |
PMC7479510
|
| MeSH |
Animals
Behavior, Animal / physiology*
Habenula
Zebrafish
|
| IF |
8.109
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(narp:GAL4VP16)rw0143a
Tg(UAS:nfsB-mCherry)rw0144 |
