論文 - 詳細
| RRC ID | 66015 |
|---|---|
| 著者 | Palumbo F, Serneels B, Pelgrims R, Yaksi E. |
| タイトル | The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors. |
| ジャーナル | Cell Rep |
| Abstract |
Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a changing environment. We show that juvenile zebrafish can perform conditioned place avoidance learning, with improving performance across development. Ablation of the dorsolateral habenula (dlHb), a brain region involved in associative learning and prediction of outcomes, leads to an unexpected improvement in performance and delayed memory extinction. Interestingly, the control animals exhibit rapid adaptation to a changing learning rule, whereas dlHb-ablated animals fail to adapt. Altogether, our results show that the dlHb plays a central role in switching animals' strategies while integrating new evidence with prior experience. |
| 巻・号 | 32(8) |
| ページ | 108054 |
| 公開日 | 2020-8-25 |
| DOI | 10.1016/j.celrep.2020.108054 |
| PII | S2211-1247(20)31039-1 |
| PMID | 32846116 |
| PMC | PMC7479510 |
| MeSH | Animals Behavior, Animal / physiology* Habenula Zebrafish |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 53 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(narp:GAL4VP16)rw0143a Tg(UAS:nfsB-mCherry)rw0144 |