論文 - 詳細
| RRC ID | 66058 |
|---|---|
| 著者 | Beiriger A, Narayan S, Singh N, Prince V. |
| タイトル | Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons. |
| ジャーナル | J Comp Neurol |
| Abstract |
In vertebrate animals, motor and sensory efferent neurons carry information from the central nervous system (CNS) to peripheral targets. These two types of efferent systems sometimes bear a close resemblance, sharing common segmental organization, axon pathways, and chemical messengers. Here, we focus on the development of the octavolateral efferent neurons (OENs) and their interactions with the closely-related facial branchiomotor neurons (FBMNs) in zebrafish. Using live-imaging approaches, we investigate the birth, migration, and projection patterns of OENs. We find that OENs are born in two distinct groups: a group of rostral efferent neurons (RENs) that arises in the fourth segment, or rhombomere (r4), of the hindbrain and a group of caudal efferent neurons (CENs) that arises in r5. Both RENs and CENs then migrate posteriorly through the hindbrain between 18 and 48 hrs postfertilization, alongside the r4-derived FBMNs. Like the FBMNs, migration of the r4-derived RENs depends on function of the segmental identity gene hoxb1a; unlike the FBMNs, however, both OEN populations move independently of prickle1b. Further, we investigate whether the previously described "pioneer" neuron that leads FBMN migration through the hindbrain is an r4-derived FBMN/REN or an r5-derived CEN. Our experiments verify that the pioneer is an r4-derived neuron and reaffirm its role in leading FBMN migration across the r4/5 border. In contrast, the r5-derived CENs migrate independently of the pioneer. Together, these results indicate that the mechanisms OENs use to navigate the hindbrain differ significantly from those employed by FBMNs. |
| 巻・号 | 529(7) |
| ページ | 1293-1307 |
| 公開日 | 2021-5-1 |
| DOI | 10.1002/cne.25021 |
| PMID | 32869305 |
| PMC | PMC8238524 |
| MeSH | Animals Cell Movement / physiology* Neurogenesis / physiology* Neurons, Efferent / physiology* Rhombencephalon / cytology* Rhombencephalon / physiology* Zebrafish |
| IF | 2.801 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(isl1:GFP) rw0 |