RRC ID 66156
著者 Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H.
タイトル Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice.
ジャーナル Sci Rep
Abstract The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress.
巻・号 11(1)
ページ 12873
公開日 2021-6-18
DOI 10.1038/s41598-021-92386-7
PII 10.1038/s41598-021-92386-7
PMID 34145364
PMC PMC8213822
MeSH Animals Conditioning, Classical Diet, High-Fat* Dopaminergic Neurons / metabolism Energy Metabolism Fasting Gene Expression Mice Mice, Transgenic Models, Animal Neurons / metabolism* Receptors, Glucocorticoid / genetics Receptors, Glucocorticoid / metabolism* Reward* Signal Transduction* Ventral Tegmental Area / cytology Ventral Tegmental Area / metabolism*
IF 3.998
リソース情報
実験動物マウス RBRC04874