| RRC ID |
66156
|
| Author |
Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H.
|
| Title |
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice.
|
| Journal |
Sci Rep
|
| Abstract |
The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress.
|
| Volume |
11(1)
|
| Pages |
12873
|
| Published |
2021-6-18
|
| DOI |
10.1038/s41598-021-92386-7
|
| PII |
10.1038/s41598-021-92386-7
|
| PMID |
34145364
|
| PMC |
PMC8213822
|
| MeSH |
Animals
Conditioning, Classical
Diet, High-Fat*
Dopaminergic Neurons / metabolism
Energy Metabolism
Fasting
Gene Expression
Mice
Mice, Transgenic
Models, Animal
Neurons / metabolism*
Receptors, Glucocorticoid / genetics
Receptors, Glucocorticoid / metabolism*
Reward*
Signal Transduction*
Ventral Tegmental Area / cytology
Ventral Tegmental Area / metabolism*
|
| IF |
3.998
|
| Resource |
| Mice |
RBRC04874 |
