論文 - 詳細
| RRC ID | 66161 |
|---|---|
| 著者 | Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, Kawamura Y, Ueda Y, Takai H, Mandai M, Kondoh E. |
| タイトル | Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells. |
| ジャーナル | Sci Rep |
| Abstract |
Placental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of these iPSCs-derived organs has alleviated liver failure or diabetes mellitus in mouse models. Here we successfully generated a three-dimensional placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud. Placental buds were transplanted to the murine uterus, where 22% of the buds were successfully engrafted. These iPSC-derived placental organ buds could serve as a new model for the study of placental function and pathology. |
| 巻・号 | 11(1) |
| ページ | 14167 |
| 公開日 | 2021-7-8 |
| DOI | 10.1038/s41598-021-93766-9 |
| PII | 10.1038/s41598-021-93766-9 |
| PMID | 34239021 |
| PMC | PMC8266876 |
| MeSH | Animals Biomarkers / metabolism Bone Morphogenetic Protein 4 / pharmacology Cell Differentiation / drug effects Cell Line Cell Lineage / drug effects Female Humans Induced Pluripotent Stem Cells / cytology* Induced Pluripotent Stem Cells / drug effects Mice, Inbred NOD Mice, SCID Placenta / cytology* Placenta / drug effects Placenta / transplantation Pregnancy Trophoblasts / cytology Trophoblasts / drug effects Trophoblasts / metabolism Uterus / physiology |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 201B7(HPS0063) 409B2(HPS0076) |