RRC ID 66252
著者 Le VVH, Davies IG, Moon CD, Wheeler D, Biggs PJ, Rakonjac J.
タイトル Novel 5-Nitrofuran-Activating Reductase in Escherichia coli.
ジャーナル Antimicrob Agents Chemother
Abstract The global spread of multidrug-resistant enterobacteria warrants new strategies to combat these pathogens. One possible approach is the reconsideration of “old” antimicrobials, which remain effective after decades of use. Synthetic 5-nitrofurans such as furazolidone, nitrofurantoin, and nitrofurazone are such a class of antimicrobial drugs.
巻・号 63(11)
公開日 2019-11-1
DOI 10.1128/AAC.00868-19
PII AAC.00868-19
PMID 31481448
PMC PMC6811407
MeSH Anti-Bacterial Agents / metabolism Anti-Bacterial Agents / pharmacology Drug Resistance, Bacterial / genetics Escherichia coli / drug effects Escherichia coli / enzymology* Escherichia coli / genetics Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism Furazolidone / chemistry Furazolidone / pharmacology Microbial Sensitivity Tests Molecular Docking Simulation Nitrofurans / metabolism Nitrofurans / pharmacology Nitrofurantoin / chemistry Nitrofurantoin / pharmacology Nitrofurazone / chemistry Nitrofurazone / pharmacology Nitroreductases / genetics Nitroreductases / metabolism* Peroxiredoxins / genetics Peroxiredoxins / metabolism
IF 4.904
リソース情報
原核生物(大腸菌) ASKA collection JW0599