| RRC ID |
6675
|
| Author |
Nomura T, Carlton JM, Baird JK, del Portillo HA, Fryauff DJ, Rathore D, Fidock DA, Su X, Collins WE, McCutchan TF, Wootton JC, Wellems TE.
|
| Title |
Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.
|
| Journal |
J Infect Dis
|
| Abstract |
Chloroquine (CQ)-resistant Plasmodium vivax malaria was first reported 12 years ago, nearly 30 years after the recognition of CQ-resistant P. falciparum. Loss of CQ efficacy now poses a severe problem for the prevention and treatment of both diseases. Mutations in a digestive vacuole protein encoded by a 13-exon gene, pfcrt, were shown recently to have a central role in the CQ resistance (CQR) of P. falciparum. Whether mutations in pfcrt orthologues of other Plasmodium species are involved in CQR remains an open question. This report describes pfcrt homologues from P. vivax, P. knowlesi, P. berghei, and Dictyostelium discoideum. Synteny between the P. falciparum and P. vivax genes is demonstrated. However, a survey of patient isolates and monkey-adapted lines has shown no association between in vivo CQR and codon mutations in the P. vivax gene. This is evidence that the molecular events underlying P. vivax CQR differ from those in P. falciparum.
|
| Volume |
183(11)
|
| Pages |
1653-61
|
| Published |
2001-6-1
|
| DOI |
10.1086/320707
|
| PII |
JID001437
|
| PMID |
11343215
|
| MeSH |
Amino Acid Sequence
Animals
Chloroquine / pharmacology*
Codon
Dictyostelium / chemistry
Dictyostelium / genetics
Drug Resistance
Humans
Molecular Chaperones / genetics*
Molecular Sequence Data
Mutation
Parasitic Sensitivity Tests
Plasmodium / chemistry
Plasmodium / drug effects*
Plasmodium / genetics
Sequence Alignment
|
| IF |
5.022
|
| Times Cited |
133
|
|
WOS Category
|
INFECTIOUS DISEASES
MICROBIOLOGY
IMMUNOLOGY
|
| Resource |
| Cellular slime molds |
G03081 |
