Reference - Detail
| RRC ID | 67028 |
|---|---|
| Author | Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, Hu T, Song H, Zhao R, Chen Y, Cui M, Zhang Y, Hughes AC, Holmes EC, Shi W. |
| Title | Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. |
| Journal | Cell |
| Abstract |
Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hotspots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV. |
| Volume | 184(17) |
| Pages | 4380-4391.e14 |
| Published | 2021-8-19 |
| DOI | 10.1016/j.cell.2021.06.008 |
| PII | S0092-8674(21)00709-1 |
| PMID | 34147139 |
| PMC | PMC8188299 |
| MeSH | Amino Acid Sequence Angiotensin-Converting Enzyme 2 / chemistry Angiotensin-Converting Enzyme 2 / metabolism Animals Asia, Southeastern COVID-19 / virology* China Chiroptera / virology* Coronavirus / classification Coronavirus / genetics* Coronavirus / isolation & purification Ecological and Environmental Phenomena Evolution, Molecular* Genome, Viral Humans Models, Molecular Phylogeny SARS-CoV-2 / genetics* SARS-CoV-2 / physiology Sequence Alignment Sequence Analysis, RNA Spike Glycoprotein, Coronavirus / chemistry Spike Glycoprotein, Coronavirus / genetics Spike Glycoprotein, Coronavirus / metabolism Viral Zoonoses |
| IF | 38.637 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1480 |
| Altmetric score changes over past 6months | 7.7 |
| Resource | |
| GBIF | Mammal specimens of Takatsuki Nature Museum (Aquapia Akutagawa) |