RRC ID 67252
著者 Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, Miki H, Himuro Y, Yoshikawa M, Matsuda H.
タイトル Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
ジャーナル Bioorg Med Chem Lett
Abstract The methanolic extract of Lawsonia inermis L. (henna) showed significant inhibitory activity toward melanogenesis in B16 melanoma 4A5 cells. Among the constituents isolated from the methanolic extract, luteolin, quercetin, and (±)-eriodictyol showed stronger inhibitory activity than the reference compound, arbutin. Several structure-activity relationships of the flavonoids were suggested, and OGlc
巻・号 25(13)
ページ 2702-6
公開日 2015-7-1
DOI 10.1016/j.bmcl.2015.04.052
PII S0960-894X(15)00384-4
PMID 25987378
MeSH Animals Antifibrinolytic Agents / chemistry Antifibrinolytic Agents / isolation & purification Antifibrinolytic Agents / pharmacology Cell Line, Tumor Cell Proliferation / drug effects Flavonoids / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* Flowers / chemistry Humans Intramolecular Oxidoreductases / antagonists & inhibitors Intramolecular Oxidoreductases / genetics Lawsonia Plant / chemistry* Melanins / biosynthesis* Melanoma, Experimental / drug therapy* Melanoma, Experimental / genetics Melanoma, Experimental / metabolism* Mice Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / genetics Oxidoreductases / antagonists & inhibitors Oxidoreductases / genetics Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Plants, Medicinal / chemistry RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Neoplasm / genetics RNA, Neoplasm / metabolism Structure-Activity Relationship
IF 2.572
リソース情報
ヒト・動物細胞 B16 melanoma 4A5(RCB0557)