論文 - 詳細
| RRC ID | 67352 |
|---|---|
| 著者 | Tsurushima H, Liu SQ, Tuboi K, Matsumura A, Yoshii Y, Nose T, Saijo K, Ohno T. |
| タイトル | Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes. |
| ジャーナル | Jpn J Cancer Res |
| Abstract |
Autologous cytotoxic T lymphocytes (CTL) against primary-cultured malignant gliomas were generated from peripheral blood mononuclear cells in vitro in 4 patients. Activities of the CTL were highly specific to the corresponding autologous glioma and were inhibited, in one patient, with antibodies against CD3, CD8 and MHC-class I molecules. When the CTL were injected 3 times into the primary-tumor-resected cavity via an Ommaya tube, reduction of the recurrent tumors with magnetic resonance imaging (MRI)-measured volumes exceeding 45 cm3 was observed in 3 patients. In a patient with glioblastoma multiforme (GBM), the tumor volume (estimated, 130 cm3) was rapidly reduced to 1/3, although re-recurrence of the tumor followed 40 days later. A slight but distinct rapid reduction of the tumor volume was observed in another GBM patient and in an anaplastic astrocytoma patient; essentially no change was observed in a further GBM patient. These results suggest that adoptive immunotherapy with autologous CTL will be clinically effective against end-stage malignant gliomas. |
| 巻・号 | 90(5) |
| ページ | 536-45 |
| 公開日 | 1999-5-1 |
| DOI | 10.1111/j.1349-7006.1999.tb00781.x |
| PII | S091050509980115X |
| PMID | 10391094 |
| PMC | PMC5926095 |
| MeSH | Adult Antigens, CD / blood Antigens, Surface / blood Disease Progression Female Glioblastoma / pathology Glioblastoma / therapy* Humans Immunophenotyping Immunotherapy, Adoptive* Magnetic Resonance Imaging Male Middle Aged T-Lymphocytes, Cytotoxic / transplantation* Transplantation, Autologous |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TUHR3TKB(RCB1187) TUHR4TKB(RCB1198) OS-RC-2(RCB0735) |