論文 - 詳細
| RRC ID | 67410 |
|---|---|
| 著者 | Liu H, Li C, Shen C, Yin F, Wang K, Liu Y, Zheng B, Zhang W, Hou X, Chen X, Wu J, Wang X, Zhong C, Zhang J, Shi H, Ai J, Zhao S. |
| タイトル | MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3. |
| ジャーナル | J Neurooncol |
| Abstract |
Glioblastoma multiforme (GBM) is the most malignant brain tumor in humans. Previous studies have demonstrated that microRNA plays important roles in the development and proliferation of GBM cells. Here we defined the mechanism by which miR-212-3p regulated the proliferation of GBM. In this study, we showed that miR-212-3p expression was significantly down-regulated and negatively correlated with serum and glucocorticoid-inducible kinase 3 (SGK3) in GBM. Either over-expression of miR-212-3p or silence of SGK3 decreased viability of GBM cells. Moreover, miR-212-3p directly bound to 3'UTR of SGK3 and inhibited its mRNA and protein expression. And over-expression of SGK3 rescued the decreased proliferation of GBM cells induced by miR-212-3p. Importantly, miR-212-3p also suppressed tumor growth in vivo. Collectively, our results demonstrated that miR-212-3p inhibited proliferation of GBM cells by directly targeting SGK3, and could potentially serve as a new therapeutic target for GBM. |
| 巻・号 | 122(3) |
| ページ | 431-9 |
| 公開日 | 2015-5-1 |
| DOI | 10.1007/s11060-015-1736-y |
| PMID | 25720694 |
| MeSH | Animals Brain Neoplasms / pathology* Cell Line, Tumor Cell Proliferation / genetics Female Gene Expression Regulation, Neoplastic / genetics* Glioblastoma / psychology* Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Humans Linear Models Male Mice Mice, Nude MicroRNAs / genetics MicroRNAs / metabolism* Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* RNA, Messenger / metabolism RNA, Small Interfering / metabolism Transfection Xenograft Model Antitumor Assays |
| IF | 3.267 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | T98G(RCB1954) U251(RCB0461) |