Reference - Detail
| RRC ID | 67416 |
|---|---|
| Author | Yamaguchi A, Usami K, Shimabe M, Hasegawa K, Asada M, Motoki K, Tahara T, Masuda K. |
| Title | The novel CA IX inhibition antibody chKM4927 shows anti-tumor efficacy in vivo. |
| Journal | Anticancer Res |
| Abstract |
Carbonic anhydrase IX (CA IX) is an attractive target for cancer therapy. Many anti-CA IX antibodies have been reported but few have been shown to possess inhibition activity. Furthermore, effective use of CA IX-inhibition antibodies for cancer immunotherapy has not been well-validated since data are mainly limited to in vitro assays. In this study, we established that chKM4927, an anti-CA IX chimeric antibody, recognizes CA IX and has CA IX-specific inhibition activity. ChKM4927 also retains antibody-dependent cellular cytotoxicity (ADCC) activity against CA IX-expressing cancer cells. Compared to controls, chKM4927 treatment (10 mg/kg) showed anti-tumor activity in the VMRC-RCW xenograft model in vivo. ChKM4927-attenuated ADCC activity showed equally effective anti-tumor activity. These results suggest that the CA IX-inhibition antibody chKM4927 has an anti-tumor effect in the VMRC-RCW xenograft model via an ADCC-independent mechanism. |
| Volume | 35(4) |
| Pages | 1997-2004 |
| Published | 2015-4-1 |
| PII | 35/4/1997 |
| PMID | 25862852 |
| MeSH | Antibodies, Monoclonal / administration & dosage* Antibody-Dependent Cell Cytotoxicity / immunology Antigens, Neoplasm / immunology* Antigens, Neoplasm / therapeutic use Carbonic Anhydrase IX Carbonic Anhydrases / immunology* Carbonic Anhydrases / therapeutic use Cell Line, Tumor Enzyme Inhibitors / administration & dosage* Enzyme Inhibitors / immunology Humans Molecular Targeted Therapy Neoplasms / immunology Neoplasms / pathology Neoplasms / therapy* Xenograft Model Antitumor Assays |
| IF | 1.994 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | OS-RC-2(RCB0735) |