| RRC ID |
67423
|
| Author |
Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M.
|
| Title |
Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.
|
| Journal |
Sci Rep
|
| Abstract |
Cancer progression involves carcinogenesis, an increase in tumour size, and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL14/BRAK (CXCL14) transgenic (Tg) mice. The rate of AOM/DSS-induced colorectal carcinogenesis in these mice was significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice. When tumour cells were injected into these mice, the size of the tumours that developed and the number of metastatic nodules in the lungs of the animals were always significantly lower in the Tg mice than in the Wt ones. Injection of anti-asialo-GM1 antibodies to the mice before and after injection of tumour cells attenuated the suppressing effects of CXCL14 on the tumor growth and metastasis, suggesting that NK cell activity played an important role during CXCL14-mediated suppression of tumour growth and metastasis. The importance of NK cells on the metastasis was also supported when CXCL14 was expressed in B16 melanoma cells. Further, the survival rates after tumour cell injection were significantly increased for the Tg mice. As these Tg mice showed no obvious abnormality, we propose that CXCL14 to be a promising molecular target for cancer suppression/prevention.
|
| Volume |
5
|
| Pages |
9083
|
| Published |
2015-3-13
|
| DOI |
10.1038/srep09083
|
| PII |
srep09083
|
| PMID |
25765541
|
| PMC |
PMC4357995
|
| MeSH |
Animals
Antigens, Ly / immunology
Autoantibodies / immunology
Cell Transformation, Neoplastic / genetics*
Cell Transformation, Neoplastic / immunology
Cell Transformation, Neoplastic / metabolism
Chemokines, CXC / genetics*
Chemokines, CXC / metabolism
Chronic Disease
Colitis / complications
Colitis / genetics
Colitis / immunology
Disease Models, Animal
Female
G(M1) Ganglioside / immunology
Galactosylceramides / metabolism
Killer Cells, Natural / immunology
Killer Cells, Natural / metabolism
Lung Neoplasms / secondary*
Lymphocyte Depletion
Melanoma, Experimental
Mice
Mice, Transgenic
NK Cell Lectin-Like Receptor Subfamily B / immunology
Neoplasms / genetics*
Neoplasms / mortality
Neoplasms / pathology*
Tumor Burden
|
| IF |
3.998
|
| Resource |
| Human and Animal Cells |
LLC(RCB0558)
B16 melanoma(RCB1283) |
