| RRC ID |
67549
|
| 著者 |
Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H.
|
| タイトル |
Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex.
|
| ジャーナル |
Nat Commun
|
| Abstract |
The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin(-/-) mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections in vivo. Draxin promotes the outgrowth of thalamic axons in vitro and this effect is abolished in thalamic neurons from Dcc and Neo1 double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors.
|
| 巻・号 |
6
|
| ページ |
10232
|
| 公開日 |
2015-12-14
|
| DOI |
10.1038/ncomms10232
|
| PII |
ncomms10232
|
| PMID |
26659141
|
| PMC |
PMC4682175
|
| MeSH |
Animals
Axons / physiology
Female
HEK293 Cells
Humans
Intercellular Signaling Peptides and Proteins / genetics
Intercellular Signaling Peptides and Proteins / metabolism*
Male
Membrane Proteins / genetics
Membrane Proteins / metabolism
Mice
Mice, Knockout
Mice, Transgenic
Neocortex / cytology
Neocortex / physiology*
Neurons / physiology
Thalamus / cytology
Thalamus / physiology
|
| IF |
12.121
|
| リソース情報 |
| ヒト・動物細胞 |
293T(RCB2202) |
