論文 - 詳細
| RRC ID | 67549 |
|---|---|
| 著者 | Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H. |
| タイトル | Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. |
| ジャーナル | Nat Commun |
| Abstract |
The thalamocortical tract carries sensory information to the neocortex. It has long been recognized that the neocortical pioneer axons of subplate neurons are essential for thalamocortical development. Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical development. In draxin(-/-) mice, thalamocortical axons do not enter the neocortex. This phenotype is sufficiently rescued by the transgenic expression of draxin in neocortical neurons. Genetic interaction data suggest that draxin acts through Deleted in colorectal cancer (DCC) and Neogenin (Neo1), to regulate thalamocortical projections in vivo. Draxin promotes the outgrowth of thalamic axons in vitro and this effect is abolished in thalamic neurons from Dcc and Neo1 double mutants. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors. |
| 巻・号 | 6 |
| ページ | 10232 |
| 公開日 | 2015-12-14 |
| DOI | 10.1038/ncomms10232 |
| PII | ncomms10232 |
| PMID | 26659141 |
| PMC | PMC4682175 |
| MeSH | Animals Axons / physiology Female HEK293 Cells Humans Intercellular Signaling Peptides and Proteins / genetics Intercellular Signaling Peptides and Proteins / metabolism* Male Membrane Proteins / genetics Membrane Proteins / metabolism Mice Mice, Knockout Mice, Transgenic Neocortex / cytology Neocortex / physiology* Neurons / physiology Thalamus / cytology Thalamus / physiology |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |