Reference - Detail
| RRC ID | 67583 |
|---|---|
| Author | Jiao X, Zhang X, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ, Chen W, Qin Y. |
| Title | Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. |
| Journal | Clin Transl Med |
| Abstract |
Immune dysregulation has long been proposed as a component of premature ovarian insufficiency (POI), but the underlying mediators and mechanisms remain largely unknown. Here we showed that patients with POI had augmented T helper 1 (TH 1) responses and regulatory T (Treg ) cell deficiency in both the periphery and the ovary compared to the control women. The increased ratio of TH 1:Treg cells was strongly correlated with the severity of POI. In mouse models of POI, the increased infiltration of TH 1 cells in the ovary resulted in follicle atresia and ovarian insufficiency, which could be prevented and reversed by Treg cells. Importantly, interferon (IFN) -γ and tumor necrosis factor (TNF) -α cooperatively promoted the apoptosis of granulosa cells and suppressed their steroidogenesis by modulating CTGF and CYP19A1. We have thus revealed a previously unrecognized Treg cell deficiency-mediated TH 1 response in the pathogenesis of POI, which should have implications for therapeutic interventions in patients with POI. |
| Volume | 11(6) |
| Pages | e448 |
| Published | 2021-6-1 |
| DOI | 10.1002/ctm2.448 |
| PMID | 34185428 |
| PMC | PMC8214854 |
| MeSH | Adult Animals Apoptosis* Female Granulosa Cells / immunology Granulosa Cells / metabolism Granulosa Cells / pathology* Humans Interferon-gamma / metabolism Mice Mice, Inbred C57BL Primary Ovarian Insufficiency / etiology Primary Ovarian Insufficiency / metabolism Primary Ovarian Insufficiency / pathology* Steroids / biosynthesis* T-Lymphocytes, Regulatory / immunology* Th1 Cells / immunology* Tumor Necrosis Factor-alpha / metabolism |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | KGN(RCB1154) |