RRC ID 67644
Author Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K.
Title Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells.
Journal Org Biomol Chem
Abstract Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities against human breast cancer (MCF-7) and human cervical epithelioid carcinoma (HeLa) cells were evaluated. Our results demonstrated that one of the type II fucoidan derivatives, 9, effectively reduced the number of viable MCF-7 and HeLa cells in a dose-dependent manner without causing cytotoxicity toward normal WI-38 cells, and that the anti-proliferative activity of 9 was comparable to that of fucoidan 2 isolated from Fucus vesiculosus. Moreover, it was found that both 2 and 9 exhibited similar apoptosis-inducing activities through activation of caspase-8 and -9 on MCF-7 and HeLa cells, respectively.
Volume 13(42)
Pages 10556-68
Published 2015-11-14
DOI 10.1039/c5ob01634g
PMID 26340595
IF 3.49
Resource
Human and Animal Cells MCF7(RCB1904) HeLa(RCB0007) WI-38(RCB0702)