| RRC ID |
67644
|
| Author |
Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K.
|
| Title |
Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells.
|
| Journal |
Org Biomol Chem
|
| Abstract |
Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities against human breast cancer (MCF-7) and human cervical epithelioid carcinoma (HeLa) cells were evaluated. Our results demonstrated that one of the type II fucoidan derivatives, 9, effectively reduced the number of viable MCF-7 and HeLa cells in a dose-dependent manner without causing cytotoxicity toward normal WI-38 cells, and that the anti-proliferative activity of 9 was comparable to that of fucoidan 2 isolated from Fucus vesiculosus. Moreover, it was found that both 2 and 9 exhibited similar apoptosis-inducing activities through activation of caspase-8 and -9 on MCF-7 and HeLa cells, respectively.
|
| Volume |
13(42)
|
| Pages |
10556-68
|
| Published |
2015-11-14
|
| DOI |
10.1039/c5ob01634g
|
| PMID |
26340595
|
| MeSH |
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology
Apoptosis
Blotting, Western
Breast Neoplasms / drug therapy*
Cell Line, Tumor
Cell Proliferation / drug effects
Cells, Cultured
Female
HeLa Cells
Humans
Immunoblotting
Microscopy, Fluorescence
Molecular Structure
Molecular Weight
Polysaccharides / chemical synthesis*
Polysaccharides / chemistry
Polysaccharides / pharmacology
|
| IF |
3.412
|
| Resource |
| Human and Animal Cells |
MCF7(RCB1904)
HeLa(RCB0007)
WI-38(RCB0702) |
