論文 - 詳細
| RRC ID | 67644 |
|---|---|
| 著者 | Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K. |
| タイトル | Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells. |
| ジャーナル | Org Biomol Chem |
| Abstract |
Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities against human breast cancer (MCF-7) and human cervical epithelioid carcinoma (HeLa) cells were evaluated. Our results demonstrated that one of the type II fucoidan derivatives, 9, effectively reduced the number of viable MCF-7 and HeLa cells in a dose-dependent manner without causing cytotoxicity toward normal WI-38 cells, and that the anti-proliferative activity of 9 was comparable to that of fucoidan 2 isolated from Fucus vesiculosus. Moreover, it was found that both 2 and 9 exhibited similar apoptosis-inducing activities through activation of caspase-8 and -9 on MCF-7 and HeLa cells, respectively. |
| 巻・号 | 13(42) |
| ページ | 10556-68 |
| 公開日 | 2015-11-14 |
| DOI | 10.1039/c5ob01634g |
| PMID | 26340595 |
| MeSH | Antineoplastic Agents / chemical synthesis Antineoplastic Agents / pharmacology Apoptosis Blotting, Western Breast Neoplasms / drug therapy* Cell Line, Tumor Cell Proliferation / drug effects Cells, Cultured Female HeLa Cells Humans Immunoblotting Microscopy, Fluorescence Molecular Structure Molecular Weight Polysaccharides / chemical synthesis* Polysaccharides / chemistry Polysaccharides / pharmacology |
| IF | 3.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) HeLa(RCB0007) WI-38(RCB0702) |