論文 - 詳細
| RRC ID | 67725 |
|---|---|
| 著者 | Kawahara T, Takahashi T, Oishi K, Tanaka H, Masuda M, Takahashi S, Takano M, Kawakami T, Fukushima K, Kanazawa H, Suzuki T. |
| タイトル | Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model. |
| ジャーナル | Microbiol Immunol |
| Abstract |
Bifidobacterium, one of the major components of intestinal microflora, shows anti-influenza virus (IFV) potential as a probiotic, partly through enhancement of innate immunity by modulation of the intestinal immune system. Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans, was isolated from healthy humans and its protective effect against IFV infection in a murine model shown. In mice that were intranasally inoculated with IFV, oral administration of MM-2 for 17 consecutive days improved clinical symptoms, reduced mortality, suppressed inflammation in the lower respiratory tract, and decreased virus titers, cell death, and pro-inflammatory cytokines such as IL-6 and TNF-α in bronchoalveolar lavage fluid. The anti-IFV mechanism of MM-2 involves innate immunity through significant increases in NK cell activities in the lungs and spleen and a significant increase in pulmonary gene expression of NK cell activators such as IFN-γ, IL-2, IL-12 and IL-18. Even in non-infected mice, MM-2 administration also induced significant enhancement of both IFN-γ production by Peyer's patch cells (PPs) and splenetic NK cell activity. Oral administration of MM-2 for 17 days activates systemic immunoreactivity in PPs, which contributes to innate immunity, including NK cell activation, resulting in an anti-IFV effect. MM-2 as a probiotic may function as a prophylactic agent in the management of an IFV epidemic. |
| 巻・号 | 59(1) |
| ページ | 1-12 |
| 公開日 | 2015-1-1 |
| DOI | 10.1111/1348-0421.12210 |
| PMID | 25400245 |
| MeSH | Administration, Oral Animals Bifidobacterium / immunology* Cytokines / biosynthesis Disease Models, Animal Female Gene Expression Profiling Influenza A Virus, H1N1 Subtype / immunology* Killer Cells, Natural / immunology* Lung / immunology Lung / pathology Mice, Inbred BALB C Orthomyxoviridae Infections / immunology* Orthomyxoviridae Infections / pathology Probiotics / administration & dosage* Spleen / immunology Sulfalene Survival Analysis |
| IF | 1.566 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | YAC-1(RCB1165) |