論文 - 詳細
| RRC ID | 67852 |
|---|---|
| 著者 | Thongsiri C, Nagai-Yoshioka Y, Yamasaki R, Adachi Y, Usui M, Nakashima K, Nishihara T, Ariyoshi W. |
| タイトル | Schizophyllum commune β-glucan: Effect on interleukin-10 expression induced by lipopolysaccharide from periodontopathic bacteria. |
| ジャーナル | Carbohydr Polym |
| Abstract |
β-glucans are potent immunomodulators, with effects on innate and adaptive immune responses via dectin-1 as the main receptor. In this study, we investigated the biological effect of β-glucan from Schizophyllum commune, called Schizophyllan (SPG) on Interleukin-10 (IL-10) expression induced by a lipopolysaccharide (LPS) from Aggregatibacter actinomycetemcomitans in murine macrophages (J774.1). SPG and dectin-1 interaction up-regulates LPS-induced IL-10 expression. The regulative effect of SPG on IL-10 expression is dependent on prolongation of nuclear translocation activity of nuclear factor-kappa B (NF-κBα) pathway induced by LPS. We also found that LPS-induced phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and cAMP-responsive-element-binding protein (CREB), followed by up-regulation of IL-10, was stimulated by SPG priming via activation of the spleen tyrosine kinase (Syk). Our data indicate that SPG augments the anti-inflammatory response in murine macrophages which can be useful to create an intervention for periodontal disease treatment. |
| 巻・号 | 253 |
| ページ | 117285 |
| 公開日 | 2021-2-1 |
| DOI | 10.1016/j.carbpol.2020.117285 |
| PII | S0144-8617(20)31458-2 |
| PMID | 33278951 |
| MeSH | Adjuvants, Immunologic / metabolism Adjuvants, Immunologic / pharmacology* Aggregatibacter actinomycetemcomitans / chemistry* Animals Fungal Polysaccharides / metabolism Fungal Polysaccharides / pharmacology* Interleukin-10 / metabolism* Lectins, C-Type / metabolism Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / immunology* Mice NF-kappa B / metabolism Pasteurellaceae Infections / drug therapy Pasteurellaceae Infections / microbiology Periodontal Diseases / drug therapy Periodontal Diseases / microbiology Phosphorylation / drug effects Schizophyllum / chemistry* Signal Transduction / drug effects Sizofiran / metabolism Sizofiran / pharmacology* |
| IF | 7.182 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |