RRC ID 6792
Author Nakao N, Ono H, Yamamura T, Anraku T, Takagi T, Higashi K, Yasuo S, Katou Y, Kageyama S, Uno Y, Kasukawa T, Iigo M, Sharp PJ, Iwasawa A, Suzuki Y, Sugano S, Niimi T, Mizutani M, Namikawa T, Ebihara S, Ueda HR, Yoshimura T.
Title Thyrotrophin in the pars tuberalis triggers photoperiodic response.
Journal Nature
Abstract Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) beta-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor-cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding.
Volume 452(7185)
Pages 317-22
Published 2008-3-20
DOI 10.1038/nature06738
PII nature06738
PMID 18354476
MeSH Animals Chickens Coturnix / anatomy & histology Coturnix / genetics Coturnix / physiology* Cyclic AMP / metabolism Darkness Enzyme Induction Female Gene Expression Regulation / radiation effects Genome Genomics Hypothalamus / metabolism Hypothalamus / radiation effects Iodide Peroxidase / biosynthesis Iodide Peroxidase / genetics Iodide Peroxidase / metabolism Light Luteinizing Hormone / metabolism Male Molecular Sequence Data Oligonucleotide Array Sequence Analysis Photoperiod* Pituitary Gland / anatomy & histology Pituitary Gland / metabolism* Pituitary Gland / radiation effects* Receptors, Thyrotropin / metabolism Reproduction / physiology* Reproduction / radiation effects* Seasons Signal Transduction / radiation effects Testis / growth & development Thyrotropin / administration & dosage Thyrotropin / antagonists & inhibitors Thyrotropin / immunology Thyrotropin / metabolism*
IF 42.779
Times Cited 296
Human and Animal Cells 293(RCB1637)