論文 - 詳細
| RRC ID | 6793 |
|---|---|
| 著者 | Chen J, Uto T, Tanigawa S, Kumamoto T, Fujii M, Hou DX. |
| タイトル | Expression profiling of genes targeted by bilberry (Vaccinium myrtillus) in macrophages through DNA microarray. |
| ジャーナル | Nutr Cancer |
| Abstract |
To evaluate the anti-inflammatory function and underlying genes targeted by bilberry, gene expression profiling through DNA microarray was performed on bilberry extract-treated macrophages. Among 22,050 oligonucleotides, the expression levels of 998 genes were increased by > or = twofold in lipopolysaccharide (LPS)-activated RAW264 cells, 358 gene signals of which were attenuated by bilberry extract (> or = 1.5-fold). Expression levels of 2,086 genes were decreased by > or = twofold in LPS-activated cells, of which 939 gene signals were enhanced by bilberry extract (> or = 1.5-fold). Utilizing Panther group analysis, 308 genes affected by bilberry extract were classified into 43 categories relating to biological processes (97), molecular functions (186), and signaling pathways (26) with > or = 1.5-fold change. The genes categorized as "defense, inflammatory response, cytokines activities, and receptor activities" were further identified, and some of them were confirmed by real-time polymerase chain reaction. The DNA microarray results provide a molecular basis for the anti-inflammatory effects of bilberry. |
| 巻・号 | 60 Suppl 1 |
| ページ | 43-50 |
| 公開日 | 2008-1-1 |
| DOI | 10.1080/01635580802381279 |
| PII | 905309992 |
| PMID | 19003580 |
| MeSH | Animals Anthocyanins / pharmacology* Anti-Inflammatory Agents / pharmacology* Cell Line Gene Expression Profiling* Lipopolysaccharides / pharmacology Macrophages / drug effects* Macrophages / metabolism Mice Microarray Analysis / methods* Plant Extracts Vaccinium myrtillus |
| IF | 2.363 |
| 引用数 | 18 |
| WOS 分野 | NUTRITION & DIETETICS ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |