論文 - 詳細
| RRC ID | 67963 |
|---|---|
| 著者 | Saita Y, Takagi T, Kitahara K, Usui M, Miyazono K, Ezura Y, Nakashima K, Kurosawa H, Ishii S, Noda M. |
| タイトル | Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia. |
| ジャーナル | J Biol Chem |
| Abstract |
Regulation of bone remodeling determines the levels of bone mass and its imbalance causes major skeletal diseases such as osteoporosis. A zinc finger protein, Schnurri-2 (SHN-2), was recently demonstrated to regulate bone morphogenetic protein-dependent adipogenesis and lymphogenesis. However, the role of SHN-2 in bone is not known. Here, we investigated the effects of Shn-2 deficiency on bone metabolism and cell function in Shn-2-null mice. Lack of SHN-2 expression reduced bone remodeling by suppressing both osteoblastic bone formation and osteoclastic bone resorption activities in vivo. Shn-2 deficiency suppressed osterix and osteocalcin expression as well as in vitro mineralization. Conversely, Shn-2 overexpression enhanced osteocalcin promoter activity and bone morphogenetic protein-dependent osteoblastic differentiation. Shn-2 deficiency suppressed Nfatc1 and c-fos expression leading to reduction of tartrate-resistant acid phosphatase-positive cell development in vivo as well as in the cultures of bone marrow cells. These studies demonstrate that SHN-2 regulates the activities of critical transcription factors required for normal bone remodeling. |
| 巻・号 | 282(17) |
| ページ | 12907-15 |
| 公開日 | 2007-4-27 |
| DOI | 10.1074/jbc.M611203200 |
| PII | S0021-9258(18)95066-0 |
| PMID | 17311925 |
| MeSH | Adipogenesis / genetics Animals Bone Marrow Cells / metabolism Bone Marrow Cells / pathology Bone Morphogenetic Proteins / biosynthesis Bone Resorption / genetics Bone Resorption / metabolism* Bone Resorption / pathology Cell Differentiation / genetics* Cells, Cultured DNA-Binding Proteins / biosynthesis DNA-Binding Proteins / deficiency* Gene Expression Regulation / genetics* Male Mice Mice, Inbred BALB C Mice, Knockout NFATC Transcription Factors / biosynthesis Osteoblasts / metabolism Osteoblasts / pathology Osteocalcin / biosynthesis Osteoclasts / metabolism Osteoclasts / pathology Osteoporosis / genetics Osteoporosis / metabolism* Osteoporosis / pathology Proto-Oncogene Proteins c-fos / biosynthesis |
| IF | 4.238 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |