論文 - 詳細
| RRC ID | 67981 |
|---|---|
| 著者 | Ohata T, Fukuda K, Takahashi M, Sugimura T, Wakabayashi K. |
| タイトル | Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids. |
| ジャーナル | Jpn J Cancer Res |
| Abstract |
Although nitric oxide (NO) is an important biological mediator, its excessive production in inflammation is thought to be a causative factor for cellular injury and, over the long term, cancer. In the present study, the effects of several fatty acids on NO production in murine macrophage cell line RAW264 cells stimulated with lipopolysaccharide were examined. Suppression of NO production was observed with the omega 3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid, in a dose-dependent fashion. In contrast, no inhibition was observed with omega 6 PUFA (linoleic acid), omega 9 PUFA (oleic acid) or a saturated fatty acid (stearic acid). Western and northern blot analyses suggested that suppression of the induction of inducible NO synthase gene expression is responsible for the inhibition of NO production by omega 3 PUFAs. The inhibitory effect of omega 3 PUFA on NO production in activated macrophages could contribute to their cancer chemopreventive influence. |
| 巻・号 | 88(3) |
| ページ | 234-7 |
| 公開日 | 1997-3-1 |
| DOI | 10.1111/j.1349-7006.1997.tb00372.x |
| PII | S0910505097841130 |
| PMID | 9140106 |
| PMC | PMC5921376 |
| MeSH | Animals Cell Line Docosahexaenoic Acids / pharmacology Eicosapentaenoic Acid / pharmacology Fatty Acids, Omega-3 / pharmacology* Kinetics Linoleic Acid Linoleic Acids / pharmacology Lipopolysaccharides / pharmacology* Macrophages / drug effects* Macrophages / enzymology Mice Nitric Oxide / biosynthesis Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase / biosynthesis* Oleic Acid / pharmacology alpha-Linolenic Acid / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |