論文 - 詳細
| RRC ID | 67994 |
|---|---|
| 著者 | Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. |
| タイトル | Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. |
| ジャーナル | Cell |
| Abstract |
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development. |
| 巻・号 | 93(2) |
| ページ | 165-76 |
| 公開日 | 1998-4-17 |
| DOI | 10.1016/s0092-8674(00)81569-x |
| PII | S0092-8674(00)81569-X |
| PMID | 9568710 |
| MeSH | Amino Acid Sequence Animals Bone Resorption Carrier Proteins* Cell Differentiation Cells, Cultured Cloning, Molecular Coculture Techniques Cytokines / genetics Cytokines / metabolism* Cytokines / pharmacology Gene Expression Regulation, Developmental Glycoproteins / metabolism* Hematopoietic Stem Cells / cytology Humans Hypercalcemia Ligands Macrophage Colony-Stimulating Factor / pharmacology Membrane Glycoproteins* Mice Molecular Sequence Data Organ Specificity Osteoclasts / cytology* Osteoclasts / metabolism* Osteoprotegerin Protein Binding RANK Ligand RNA, Messenger / analysis Rats Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear* Receptors, Tumor Necrosis Factor Recombinant Fusion Proteins |
| IF | 38.637 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 166 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |