RRC ID 67994
著者 Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ.
タイトル Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
ジャーナル Cell
Abstract The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.
巻・号 93(2)
ページ 165-76
公開日 1998-4-17
DOI 10.1016/s0092-8674(00)81569-x
PII S0092-8674(00)81569-X
PMID 9568710
MeSH Amino Acid Sequence Animals Bone Resorption Carrier Proteins* Cell Differentiation Cells, Cultured Cloning, Molecular Coculture Techniques Cytokines / genetics Cytokines / metabolism* Cytokines / pharmacology Gene Expression Regulation, Developmental Glycoproteins / metabolism* Hematopoietic Stem Cells / cytology Humans Hypercalcemia Ligands Macrophage Colony-Stimulating Factor / pharmacology Membrane Glycoproteins* Mice Molecular Sequence Data Organ Specificity Osteoclasts / cytology* Osteoclasts / metabolism* Osteoprotegerin Protein Binding RANK Ligand RNA, Messenger / analysis Rats Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear* Receptors, Tumor Necrosis Factor Recombinant Fusion Proteins
IF 38.637
リソース情報
ヒト・動物細胞 ST2(RCB0224)