RRC ID 6810
Author Ohshima S, Seyama A.
Title Cellular aging and centrosome aberrations.
Journal Ann. N. Y. Acad. Sci.
Abstract 2/cell) centrosomes and misaligned chromosomes in later passages in all strains examined. Numerical centrosome aberrations were prominent in a polyploid subpopulation. In metaphase cells, numerical centrosome aberrations were correlated significantly with chromosome misalignment. Fluorescent in situ hybridization analysis using a centromere-specific probe revealed a correlation between chromosome aneusomy and centrosome over-duplication. These results suggest that abnormal duplication of centrosomes in association with cellular aging may be responsible for the increase in chromosomal instability with aging.
Volume 1197
Pages 108-17
Published 2010-6
DOI 10.1111/j.1749-6632.2009.05396.x
PMID 20536839
MeSH Aging / genetics Cell Cycle / genetics Cellular Senescence / genetics* Centrosome / pathology* Chromosomal Instability Fibroblasts / metabolism Humans Laser Scanning Cytometry Metaphase Mitosis Polyploidy
IF 4.277
Times Cited 8
Human and Animal Cells