| RRC ID |
6822
|
| Author |
Ogawa T, Furukawa T, Shiga K, Hashimoto S, Ogawa K, Kobayashi T, Horii A.
|
| Title |
A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.
|
| Journal |
Eur Arch Otorhinolaryngol
|
| Abstract |
We analyzed the cis-diamminedichloroplatinum (CDDP) susceptibility of ten head and neck squamous cell carcinoma (HNSCC) cell lines and found that this susceptibility varied significantly among the cell lines. Apoptotic cell death was predominant after the CDDP treatment, and a significant association was observed between the induction of apoptosis and the CDDP susceptibility. An analysis using a cDNA microarray consisting of 23,040 genes identified 52 genes that showed altered expression patterns between super-sensitive and super-resistant cell lines after the CDDP treatments. Using these 52 genes, we successfully distinguished the super-resistant cell lines from others. Our present results give us valuable clues to better understand the chemosensitivities of such cells to CDDP. This will improve the clinical management of patients with HNSCC.
|
| Volume |
267(1)
|
| Pages |
123-9
|
| Published |
2010-1-1
|
| DOI |
10.1007/s00405-009-0976-x
|
| PMID |
19381670
|
| MeSH |
Antineoplastic Agents / therapeutic use*
Apoptosis / drug effects
Apoptosis / genetics
Blotting, Western
Carcinoma / drug therapy
Carcinoma / genetics
Carcinoma / pathology
Carcinoma, Squamous Cell
Cell Line, Tumor
Cisplatin / therapeutic use*
DNA, Complementary / analysis*
DNA, Complementary / genetics
DNA, Neoplasm / analysis*
DNA, Neoplasm / genetics
Flow Cytometry
Genes, Neoplasm / genetics*
Head and Neck Neoplasms / drug therapy
Head and Neck Neoplasms / genetics
Head and Neck Neoplasms / pathology
Humans
Neoplasms, Squamous Cell / drug therapy
Neoplasms, Squamous Cell / genetics
Neoplasms, Squamous Cell / pathology
Oligonucleotide Array Sequence Analysis / methods*
Reverse Transcriptase Polymerase Chain Reaction
Squamous Cell Carcinoma of Head and Neck
|
| IF |
1.809
|
| Times Cited |
3
|
|
WOS Category
|
OTORHINOLARYNGOLOGY
|
| Resource |
| Human and Animal Cells |
HSQ-89(RCB0789) |
