Reference - Detail
| RRC ID | 6828 |
|---|---|
| Author | Veeranarayanan S, Poulose AC, Mohamed MS, Varghese SH, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS. |
| Title | Synergistic targeting of cancer and associated angiogenesis using triple-targeted dual-drug silica nanoformulations for theragnostics. |
| Journal | Small |
| Abstract |
The targeting and therapeutic efficacy of dye- and dual-drug-loaded silica nanoparticles, functionalized with triple targeting ligands specific towards cancer and neoangiogenesis simultaneously, are discussed. This synergized, high-precision, multitarget concept culminates in an elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency, thereby imparting superior therapeutic efficacy against breast cancer cells and completely disabling the migration and angiogenic sprouting ability of activated endothelial cells. The exceptional multimodal efficiency achieved by this single therapeutic nanoformulation holds promise for the synergistic targeting and treatment of the yet elusive cancer and its related angiogenesis in a single, lethal shot. |
| Volume | 8(22) |
| Pages | 3476-89 |
| Published | 2012-11-19 |
| DOI | 10.1002/smll.201200874 |
| PMID | 22865683 |
| MeSH | Angiogenesis Inhibitors / chemistry Animals Breast Neoplasms / drug therapy Cell Line Cell Proliferation / drug effects Cetrimonium Cetrimonium Compounds / chemistry Drug Delivery Systems Drug Synergism Endothelial Cells / drug effects Female Fluorescent Dyes / chemistry Human Umbilical Vein Endothelial Cells Humans Ligands Lipids / chemistry MCF-7 Cells Mice Microscopy, Electron, Transmission Microscopy, Fluorescence Nanomedicine / methods* Nanoparticles Neoplasms / therapy* Neovascularization, Pathologic* Polyethylene Glycols / chemistry Silicon Dioxide / chemistry |
| IF | 5.145 |
| Times Cited | 236 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MCF7(RCB1904) L929 |