| RRC ID |
6828
|
| Author |
Veeranarayanan S, Poulose AC, Mohamed MS, Varghese SH, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS.
|
| Title |
Synergistic targeting of cancer and associated angiogenesis using triple-targeted dual-drug silica nanoformulations for theragnostics.
|
| Journal |
Small
|
| Abstract |
The targeting and therapeutic efficacy of dye- and dual-drug-loaded silica nanoparticles, functionalized with triple targeting ligands specific towards cancer and neoangiogenesis simultaneously, are discussed. This synergized, high-precision, multitarget concept culminates in an elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency, thereby imparting superior therapeutic efficacy against breast cancer cells and completely disabling the migration and angiogenic sprouting ability of activated endothelial cells. The exceptional multimodal efficiency achieved by this single therapeutic nanoformulation holds promise for the synergistic targeting and treatment of the yet elusive cancer and its related angiogenesis in a single, lethal shot.
|
| Volume |
8(22)
|
| Pages |
3476-89
|
| Published |
2012-11-19
|
| DOI |
10.1002/smll.201200874
|
| PMID |
22865683
|
| MeSH |
Angiogenesis Inhibitors / chemistry
Animals
Breast Neoplasms / drug therapy
Cell Line
Cell Proliferation / drug effects
Cetrimonium
Cetrimonium Compounds / chemistry
Drug Delivery Systems
Drug Synergism
Endothelial Cells / drug effects
Female
Fluorescent Dyes / chemistry
Human Umbilical Vein Endothelial Cells
Humans
Ligands
Lipids / chemistry
MCF-7 Cells
Mice
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Nanomedicine / methods*
Nanoparticles
Neoplasms / therapy*
Neovascularization, Pathologic*
Polyethylene Glycols / chemistry
Silicon Dioxide / chemistry
|
| IF |
5.145
|
| Times Cited |
236
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
MCF7(RCB1904)
L929 |
