| RRC ID |
68639
|
| 著者 |
Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, Ma JX, Liu Z, Zhou Y.
|
| タイトル |
Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury.
|
| ジャーナル |
PLoS One
|
| Abstract |
SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20 µg/eye/day) for 7 days significantly decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also ameliorated the corneal inflammation as evaluated by the inflammatory index. Furthermore, SERPINA3K enhanced the recovery of corneal epithelium after the alkali injury. Toward the mechanism of action, SERPINA3K down-regulated the expression of the pro-angiogenic and pro-inflammatory factors, vascular endothelial growth factor and tumor necrosis factor-α and up-regulated the expression of the anti-angiogenic factor, pigment epithelium-derived factor. SERPINA3K specifically inhibited growth of vascular endothelial cells. Meanwhile, SERPINA3K significantly up-regulated the expression of EGFR in the corneal epithelium. These findings suggest that SERPINA3K has therapeutic potential for corneal inflammation and NV.
|
| 巻・号 |
6(1)
|
| ページ |
e16712
|
| 公開日 |
2011-1-31
|
| DOI |
10.1371/journal.pone.0016712
|
| PMID |
21304961
|
| PMC |
PMC3031620
|
| MeSH |
Angiogenesis Inhibitors / administration & dosage
Angiogenesis Inhibitors / pharmacology
Angiogenesis Modulating Agents / analysis
Animals
Anti-Inflammatory Agents / administration & dosage
Anti-Inflammatory Agents / pharmacology
Cornea / blood supply
Cornea / pathology
Corneal Injuries*
Corneal Neovascularization / drug therapy*
Eye Burns / chemically induced
Gene Expression Regulation / drug effects
Inflammation / drug therapy*
Inflammation Mediators / analysis
Models, Animal
Rats
Serpins / administration & dosage
Serpins / pharmacology*
Serpins / therapeutic use
|
| IF |
2.74
|
| リソース情報 |
| ヒト・動物細胞 |
HCE-T(RCB2280) |
