論文 - 詳細
RRC ID | 68704 |
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著者 | Burdeos GC, Nakagawa K, Watanabe A, Kimura F, Miyazawa T. |
タイトル | γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. |
ジャーナル | J Nutr Sci Vitaminol (Tokyo) |
Abstract |
Vitamin E is the generic name for tocopherol (Toc) and tocotrienol (T3), which have saturated and unsaturated side chains, respectively. Such differences allow T3 to be different from Toc in terms of their functions. T3 has been known to attenuate cholesterol (Cho) level by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR). Recent reports also showed the efficacy of T3 in improving triglyceride (TG) profiles in both in vivo and in vitro studies. However the mechanism involved in this biological activity is still unclear and needs to be further investigated. In the present study, we elucidated the effect of γ-T3 on lipid levels and lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. γ-T3 showed attenuation of TG through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6. In contrast, the Cho level remained unchanged. These results expanded our previous finding of lipid-lowering effects of T3, especially for TG. Therefore, T3 is a potential lipid-lowering compound candidate with realistic prospects for its use as a therapy for lipid-related diseases in humans. |
巻・号 | 59(2) |
ページ | 148-51 |
公開日 | 2013-1-1 |
DOI | 10.3177/jnsv.59.148 |
PII | DN/JST.JSTAGE/jnsv/59.148 |
PMID | 23727646 |
MeSH | Animals Carcinoma, Hepatocellular / metabolism Carnitine O-Palmitoyltransferase / genetics Carnitine O-Palmitoyltransferase / metabolism Cell Line, Tumor Cholesterol / blood Chromans / pharmacology* Fatty Acid Synthases / genetics Fatty Acid Synthases / metabolism Gene Expression / drug effects Hydroxymethylglutaryl CoA Reductases / metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Lipogenesis Liver Neoplasms / metabolism Mice Mice, Inbred C57BL RNA, Messenger / genetics RNA, Messenger / metabolism Stearoyl-CoA Desaturase / genetics Stearoyl-CoA Desaturase / metabolism Sterol Regulatory Element Binding Protein 1 / genetics Sterol Regulatory Element Binding Protein 1 / metabolism Triglycerides / blood* Vitamin E / analogs & derivatives* Vitamin E / pharmacology |
IF | 1.424 |
リソース情報 | |
ヒト・動物細胞 | Hepa 1-6(RCB1638) |