論文 - 詳細
| RRC ID | 68753 |
|---|---|
| 著者 | Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A. |
| タイトル | Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy. |
| ジャーナル | Sci Rep |
| Abstract |
Zn-, and Mg-containing tricalcium phosphates (TCPs) loaded with a hydrothermal extract of a human tubercle bacillus (HTB) were prepared by immersing Zn-TCP and Mg-TCP in HTB-containing supersaturated calcium phosphate solutions. The in vitro and in vivo immunogenic activities of the HTB-loaded Zn-, and Mg-TCPs (Zn-Ap-HTB and Mg-Ap-HTB, respectively) were evaluated as potential immunopotentiating adjuvants for cancer immunotherapy. The Zn-Ap-HTB and Mg-Ap-HTB adjuvants showed no obvious cytotoxicity and more effectively stimulated granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion by macrophage-like cells than unprocessed HTB or HTB-loaded TCP (T-Ap-HTB) in vitro. Zn-Ap-HTB and Mg-Ap-HTB mixed with liquid-nitrogen-treated tumor tissue markedly inhibited the in vivo development of rechallenged Lewis lung carcinoma (LLC) cells compared with T-Ap-HTB and the unprocessed HTB mixed liquid-nitrogen-treated tumor tissue. Zn-Ap-HTB and Mg-Ap-HTB contributed to eliciting potent systemic antitumor immunity in vivo. |
| 巻・号 | 3 |
| ページ | 2203 |
| 公開日 | 2013-1-1 |
| DOI | 10.1038/srep02203 |
| PII | srep02203 |
| PMID | 23857555 |
| PMC | PMC3712317 |
| MeSH | Adjuvants, Immunologic* Animals Bacillus / chemistry Bacillus / immunology Calcium Phosphates / administration & dosage Calcium Phosphates / chemistry* Calcium Phosphates / immunology* Calcium Phosphates / toxicity Cancer Vaccines* / administration & dosage Cancer Vaccines* / chemistry Cancer Vaccines* / immunology Cancer Vaccines* / toxicity Cytokines / biosynthesis Disease Models, Animal Female Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis Humans Immunotherapy* Macrophages / immunology Macrophages / metabolism Magnesium / chemistry Mice Neoplasms / immunology* Neoplasms / mortality Neoplasms / therapy* Spleen / immunology Spleen / metabolism Vaccines, Conjugate Zinc / chemistry |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1(RCB1189) LLC(RCB0558) |