Reference - Detail
| RRC ID | 68790 |
|---|---|
| Author | Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. |
| Title | Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. |
| Journal | Nat Struct Mol Biol |
| Abstract |
RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important structural component of the nuclear matrix. However, the molecular identities, functional roles and localization dynamics of lncRNAs that influence nuclear architecture remain poorly understood. Here, we describe one lncRNA, Firre, that interacts with the nuclear-matrix factor hnRNPU through a 156-bp repeating sequence and localizes across an ~5-Mb domain on the X chromosome. We further observed Firre localization across five distinct trans-chromosomal loci, which reside in spatial proximity to the Firre genomic locus on the X chromosome. Both genetic deletion of the Firre locus and knockdown of hnRNPU resulted in loss of colocalization of these trans-chromosomal interacting loci. Thus, our data suggest a model in which lncRNAs such as Firre can interface with and modulate nuclear architecture across chromosomes. |
| Volume | 21(2) |
| Pages | 198-206 |
| Published | 2014-2-1 |
| DOI | 10.1038/nsmb.2764 |
| PII | nsmb.2764 |
| PMID | 24463464 |
| PMC | PMC3950333 |
| MeSH | Animals Base Sequence Chromatin / metabolism Chromosomes / metabolism* Chromosomes / ultrastructure Embryonic Stem Cells Female Humans Male Mice Models, Genetic* Molecular Sequence Data RNA, Long Noncoding / analysis RNA, Long Noncoding / chemistry RNA, Long Noncoding / physiology* Sequence Analysis, RNA X Chromosome Inactivation |
| IF | 11.98 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | BRC6(AES0010) |