Reference - Detail
| RRC ID | 68800 |
|---|---|
| Author | Alam MT, Nagao-Kitamoto H, Ohga N, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y, Hida K. |
| Title | Suprabasin as a novel tumor endothelial cell marker. |
| Journal | Cancer Sci |
| Abstract |
Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker. |
| Volume | 105(12) |
| Pages | 1533-40 |
| Published | 2014-12-1 |
| DOI | 10.1111/cas.12549 |
| PMID | 25283635 |
| PMC | PMC4317965 |
| MeSH | Animals Antigens, Differentiation / genetics Antigens, Differentiation / metabolism* Biomarkers, Tumor / metabolism Cell Line, Tumor Endothelial Cells / metabolism Endothelial Cells / pathology* Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Mice Mice, Nude Neoplasm Metastasis / pathology Neoplasm Proteins / genetics Neoplasm Proteins / metabolism* Neoplasms / metabolism Neoplasms / pathology* Neovascularization, Pathologic / metabolism Signal Transduction |
| IF | 4.966 |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | OS-RC-2(RCB0735) |