RRC ID 68
著者 Tanaka Y, Kuroiwa T, Miyasaka N, Tanabe F, Nagaoka T, Ohno K.
タイトル Recovery of apparent diffusion coefficient after embolic stroke does not signify complete salvage of post-ischemic neuronal tissue.
ジャーナル Acta Neurochir Suppl
Abstract BACKGROUND AND PURPOSE:It has been shown in previous studies that recovery of apparent diffusion coefficient (ADC) of water is not necessarily associated with a reversal of tissue damage. We examined the relationships between temporal ADC change and histological outcome after embolic stroke in rat using an experimental MRI scanner.
SUBJECTS AND METHODS:Male Wistar rats underwent embolization of the right middle cerebral artery with autologous clot. ADC and relative cerebral blood flow (rCBF) were measured consecutively for 3 hours after embolization. The brains were prepared for histological examination.
RESULTS:Transient decline of ADC was observed during the initial 2 hours after embolization. In these areas, serial rCBF measurement revealed incomplete recovery. In some other areas, ADC decrease without rCBF recovery was observed during 3 hours postischemia. Histological examination revealed infarction in areas with persistent ADC decrease. Scattered neuronal death was noticeable in areas with a transient--in some areas less than 0.5 hour--ADC decrease.
CONCLUSION:Consecutive MRI analysis demonstrated postischemic transient ADC decrease in an embolic stroke model of rat. The normalization of ADC does not signify normalization of postischemic tissue, since the areas often evolve postischemic neuronal death at a later time.
巻・号 86
ページ 141-5
公開日 2003-1-1
DOI 10.1007/978-3-7091-0651-8_30
PMID 14753422
MeSH Animals Brain / metabolism* Brain / pathology Brain / physiopathology Cell Death Cerebral Infarction / etiology Cerebral Infarction / pathology Cerebral Infarction / physiopathology Diffusion Diffusion Magnetic Resonance Imaging Intracranial Embolism / complications* Male Rats Rats, Wistar Recovery of Function Stroke / diagnosis Stroke / etiology* Stroke / metabolism* Stroke / pathology Time Factors
引用数 6
WOS 分野 CLINICAL NEUROLOGY NEUROIMAGING
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