| RRC ID |
69000
|
| Author |
Harada Y, Yamada M, Imayoshi I, Kageyama R, Suzuki Y, Kuniya T, Furutachi S, Kawaguchi D, Gotoh Y.
|
| Title |
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module.
|
| Journal |
Nat Commun
|
| Abstract |
Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone are derived from a subpopulation of embryonic neural stem-progenitor cells (NPCs) that is characterized by a slower cell cycle relative to the more abundant rapid cycling NPCs that build the brain. Yet, how slow cell cycle can cause the establishment of adult NSCs remains largely unknown. Here, we demonstrate that Notch and an effector Hey1 form a module that is upregulated by cell cycle arrest in slowly dividing NPCs. In contrast to the oscillatory expression of the Notch effectors Hes1 and Hes5 in fast cycling progenitors, Hey1 displays a non-oscillatory stationary expression pattern and contributes to the long-term maintenance of NSCs. These findings reveal a novel division of labor in Notch effectors where cell cycle rate biases effector selection and cell fate.
|
| Volume |
12(1)
|
| Pages |
6562
|
| Published |
2021-11-12
|
| DOI |
10.1038/s41467-021-26605-0
|
| PII |
10.1038/s41467-021-26605-0
|
| PMID |
34772946
|
| PMC |
PMC8589987
|
| MeSH |
Adult Stem Cells / metabolism*
Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism
Brain / cytology
Cell Cycle / genetics
Cell Cycle / physiology
Cell Cycle Checkpoints / genetics
Cell Cycle Checkpoints / physiology*
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism*
Embryonic Stem Cells
Gene Expression
Lateral Ventricles / metabolism
Mice
Nervous System
Neurogenesis / genetics
Neurogenesis / physiology*
Receptor, Notch1
Repressor Proteins / metabolism
|
| IF |
12.121
|
| Resource |
| Mice |
RBRC01151
RBRC02707 |
