論文 - 詳細
| RRC ID | 69084 |
|---|---|
| 著者 | Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S. |
| タイトル | Relationship between methyl CpG binding protein 2 and JC viral proteins. |
| ジャーナル | Jpn J Infect Dis |
| Abstract |
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression. |
| 巻・号 | 66(2) |
| ページ | 126-32 |
| 公開日 | 2013-1-1 |
| DOI | 10.7883/yoken.66.126 |
| PII | DN/JST.JSTAGE/yoken/66.126 |
| PMID | 23514909 |
| MeSH | Cell Line Gene Expression Profiling Gene Expression Regulation* Host-Pathogen Interactions* Humans JC Virus / pathogenicity* Methyl-CpG-Binding Protein 2 / biosynthesis* Methyl-CpG-Binding Protein 2 / genetics RNA, Messenger / biosynthesis RNA, Messenger / genetics Viral Proteins / biosynthesis* |
| IF | 1.24 |
| リソース情報 | |
| ヒト・動物細胞 | SK-N-SH(RCB0426) CACO-2(RCB0988) 293T(RCB2202) MCF7(RCB1904) |