論文 - 詳細
| RRC ID | 69131 |
|---|---|
| 著者 | Tanaka YT, Tanaka K, Kojima H, Hamada T, Masutani T, Tsuboi M, Akao Y. |
| タイトル | Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B. |
| ジャーナル | Bioorg Med Chem Lett |
| Abstract |
Aging of skin is characterized by skin wrinkling, laxity, and pigmentation induced by several environmental stress factors. Histological changes during the photoaging of skin include hyperproliferation of keratinocytes and melanocytes causing skin wrinkles and pigmentation. Nuclear factor kappa B (NF-κB) is one of the representative transcription factors active in conjunction with inflammation. NF-κB is activated by stimulation such as ultraviolet rays and inflammatory cytokines and induces the expression of various genes such as those of basic fibroblast growth factor (bFGF) and matrix metalloprotease-1 (MMP-1). We screened several plant extracts for their possible inhibitory effect on the transcriptional activity of NF-κB. One of them, an extract from Cynara scolymus L., showed a greatest effect on the suppression of NF-κB transactivation. As a result, we found that cynaropicrin, which is a sesquiterpene lactone, inhibited the NF-κB-mediated transactivation of bFGF and MMP-1. Furthermore, it was confirmed that in an in vivo mouse model cynaropicrin prevented skin photoaging processes leading to the hyperproliferation of keratinocytes and melanocytes. These findings taken together indicate that cynaropicrin is an effective antiphotoaging agent that acts by inhibiting NF-κB-mediated transactivation. |
| 巻・号 | 23(2) |
| ページ | 518-23 |
| 公開日 | 2013-1-15 |
| DOI | 10.1016/j.bmcl.2012.11.034 |
| PII | S0960-894X(12)01477-1 |
| PMID | 23232059 |
| MeSH | Animals Cells, Cultured Cynara scolymus / chemistry* Disease Models, Animal Lactones / pharmacology* Mice NF-kappa B / antagonists & inhibitors* NF-kappa B / genetics Plant Extracts / chemistry* Sesquiterpenes / pharmacology* Skin Aging / drug effects* Transcription, Genetic / drug effects* |
| IF | 2.572 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293(RCB1637) |